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import wx

class MyFrame(wx.Frame):

    def __init__(self, parent, title):

        wx.Frame.__init__(self, parent, -1, title )

        btn = wx.Button(self, -1, "Hola")

        self.Bind(wx.EVT_BUTTON, self.say_hello, btn)

    def say_hello(self,*arg):

        print "hola todo el mundo!"

class MyApp(wx.App):

    def OnInit(self):

        frame = MyFrame(None, "Simple wxPython App")

        frame.Show(True)

        return True

MyApp().MainLoop()